{ "_id": "6a1027f4acfb0bcc41c906a8", "Package": "dtpcrm", "Type": "Package", "Title": "Dose Transition Pathways for Continual Reassessment Method", "Version": "0.1.1", "Authors@R": "c(person(\"Christina\", \"Yap\", email = \"yapchristina17@gmail.com\",\nrole = c(\"aut\", \"cre\")),\nperson(\"Daniel\", \"Slade\", email = \"D.Slade@bham.ac.uk\",\nrole = c(\"aut\")),\nperson(\"Kristian\", \"Brock\", email = \"k.brock@bham.ac.uk\",\nrole = c(\"aut\")),\nperson(\"Yi\", \"Pan\", email = \"ypan1988@gmail.com\",\nrole = c(\"aut\")))", "Maintainer": "Christina Yap ", "Description": "Provides the dose transition pathways (DTP) to project in\nadvance the doses recommended by a model-based design for\nsubsequent patients (stay, escalate, deescalate or stop early)\nusing all the accumulated toxicity information; See Yap et al\n(2017) . DTP can be used as\na design and an operational tool and can be displayed as a\ntable or flow diagram. The 'dtpcrm' package also provides the\nmodified continual reassessment method (CRM) and time-to-event\nCRM (TITE-CRM) with added practical considerations to allow\nstopping early when there is sufficient evidence that the\nlowest dose is too toxic and/or there is a sufficient number of\npatients dosed at the maximum tolerated dose.", "License": "GPL (>= 2)", "Encoding": "UTF-8", "VignetteBuilder": "knitr", "RoxygenNote": "6.1.1", "NeedsCompilation": "no", "Packaged": { "Date": "2026-05-13 08:14:14 UTC", "User": "root" }, "Author": "Christina Yap [aut, cre], Daniel Slade [aut], Kristian Brock\n[aut], Yi Pan [aut]", "Repository": "https://christinayap.r-universe.dev", "Date/Publication": "2019-08-20 10:20:02 UTC", "RemoteUrl": "https://github.com/cran/dtpcrm", "RemoteRef": "HEAD", "RemoteSha": "406e20eb56c089d2b68105ccf2fc4db153495bd2", "MD5sum": "aa001bf4af15e9902cd1b8d1b138aa07", "_user": "christinayap", "_type": "src", "_file": "dtpcrm_0.1.1.tar.gz", "_fileid": 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"knitr", "role": "Suggests" }, { "package": "rmarkdown", "role": "Suggests" }, { "package": "testthat", "role": "Suggests" } ], "_owner": "cran", "_selfowned": true, "_usedby": 0, "_updates": [], "_tags": [], "_stars": 0, "_contributors": [ { "user": "christinayap", "count": 2, "uuid": 48917791 } ], "_userbio": { "uuid": 48917791, "type": "user", "name": "ChristinaYap" }, "_downloads": { "count": 205, "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/dtpcrm" }, "_searchresults": 12, "_rbuild": "4.6.0", "_assets": [ "extra/citation.cff", "extra/citation.html", "extra/citation.json", "extra/citation.txt", "extra/contents.json", "extra/dtpcrm.html", "manual.pdf" ], "_realowner": "christinayap", "_cranurl": false, "_releases": [ { "version": "0.1.0", "date": "2019-04-10" }, { "version": "0.1.1", "date": "2019-08-20" } ], "_exports": [ "applied_crm", "applied_crm_sim", "applied_titecrm", "applied_titecrm_sim", "applied_titecrmts_sim", "calculate_dtps", "dtpflow", "plot_crm", "stop_for_consensus_reached", "stop_for_excess_toxicity_empiric", "stop_for_excess_toxicity_logistic", "stop_for_sample_size", "summary_crm" ], "_help": [ { "page": "applied_crm", "title": "Execute the CRM", "topics": [ "applied_crm" ] }, { "page": "applied_crm_sim", "title": "Simulate CRM trials using specified design options", "topics": [ "applied_crm_sim" ] }, { "page": "applied_titecrm", "title": "Execute the TITE-CRM", "topics": [ "applied_titecrm" ] }, { "page": "applied_titecrm_sim", "title": "Simulate TITE-CRM trials using specified design options", "topics": [ "applied_titecrm_sim" ] }, { "page": "applied_titecrmts_sim", "title": "Simulate TITE-CRM trials using specified design options", "topics": [ "applied_titecrmts_sim" ] }, { "page": "calculate_dtps", "title": "Produce the Dose Transition Pathways", "topics": [ "calculate_dtps" ] }, { "page": "dtpflow", "title": "Produce DTP flow diagram", "topics": [ "dtpflow" ] }, { "page": "plot_crm", "title": "Plot of posterior estimates from the CRM", "topics": [ "plot_crm" ] }, { "page": "stop_for_consensus_reached", "title": "Stopping for consensus", "topics": [ "stop_for_consensus_reached" ] }, { "page": "stop_for_excess_toxicity_empiric", "title": "Stopping for excess toxicity - Empiric method", "topics": [ "stop_for_excess_toxicity_empiric" ] }, { "page": "stop_for_excess_toxicity_logistic", "title": "Stopping for excess toxicity - Logistic method", "topics": [ "stop_for_excess_toxicity_logistic" ] }, { "page": "stop_for_sample_size", "title": "Stopping for sample size reached", "topics": [ "stop_for_sample_size" ] }, { "page": "summary_crm", "title": "Provide a summary of applied_crm output", "topics": [ "summary_crm" ] } ], "_rundeps": [ "dfcrm", "diagram", "shape" ], "_vignettes": [ { "source": "dtpcrm_vignettev02.Rmd", "filename": "dtpcrm_vignettev02.html", "title": "dtpcrm: Dose Transition Pathways with Continual Reassessment Method", "author": "Christina Yap, Daniel Slade", "engine": 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