Package: dtpcrm 0.1.1
dtpcrm: Dose Transition Pathways for Continual Reassessment Method
Provides the dose transition pathways (DTP) to project in advance the doses recommended by a model-based design for subsequent patients (stay, escalate, deescalate or stop early) using all the accumulated toxicity information; See Yap et al (2017) <doi:10.1158/1078-0432.CCR-17-0582>. DTP can be used as a design and an operational tool and can be displayed as a table or flow diagram. The 'dtpcrm' package also provides the modified continual reassessment method (CRM) and time-to-event CRM (TITE-CRM) with added practical considerations to allow stopping early when there is sufficient evidence that the lowest dose is too toxic and/or there is a sufficient number of patients dosed at the maximum tolerated dose.
Authors:
dtpcrm_0.1.1.tar.gz
dtpcrm_0.1.1.zip(r-4.5)dtpcrm_0.1.1.zip(r-4.4)dtpcrm_0.1.1.zip(r-4.3)
dtpcrm_0.1.1.tgz(r-4.4-any)dtpcrm_0.1.1.tgz(r-4.3-any)
dtpcrm_0.1.1.tar.gz(r-4.5-noble)dtpcrm_0.1.1.tar.gz(r-4.4-noble)
dtpcrm_0.1.1.tgz(r-4.4-emscripten)dtpcrm_0.1.1.tgz(r-4.3-emscripten)
dtpcrm.pdf |dtpcrm.html✨
dtpcrm/json (API)
| # Install 'dtpcrm' in R: |
| install.packages('dtpcrm', repos = c('https://christinayap.r-universe.dev', 'https://cloud.r-project.org')) |
This package does not link to any Github/Gitlab/R-forge repository. No issue tracker or development information is available.
Last updated 5 years agofrom:406e20eb56. Checks:OK: 3 NOTE: 4. Indexed: yes.
| Target | Result | Date |
|---|---|---|
| Doc / Vignettes | OK | Aug 27 2024 |
| R-4.5-win | NOTE | Aug 27 2024 |
| R-4.5-linux | NOTE | Aug 27 2024 |
| R-4.4-win | NOTE | Aug 27 2024 |
| R-4.4-mac | NOTE | Aug 27 2024 |
| R-4.3-win | OK | Aug 27 2024 |
| R-4.3-mac | OK | Aug 27 2024 |
Exports:applied_crmapplied_crm_simapplied_titecrmapplied_titecrm_simapplied_titecrmts_simcalculate_dtpsdtpflowplot_crmstop_for_consensus_reachedstop_for_excess_toxicity_empiricstop_for_excess_toxicity_logisticstop_for_sample_sizesummary_crm
Readme and manuals
Help Manual
| Help page | Topics |
|---|---|
| Execute the CRM | applied_crm |
| Simulate CRM trials using specified design options | applied_crm_sim |
| Execute the TITE-CRM | applied_titecrm |
| Simulate TITE-CRM trials using specified design options | applied_titecrm_sim |
| Simulate TITE-CRM trials using specified design options | applied_titecrmts_sim |
| Produce the Dose Transition Pathways | calculate_dtps |
| Produce DTP flow diagram | dtpflow |
| Plot of posterior estimates from the CRM | plot_crm |
| Stopping for consensus | stop_for_consensus_reached |
| Stopping for excess toxicity - Empiric method | stop_for_excess_toxicity_empiric |
| Stopping for excess toxicity - Logistic method | stop_for_excess_toxicity_logistic |
| Stopping for sample size reached | stop_for_sample_size |
| Provide a summary of applied_crm output | summary_crm |
